Word: tnp
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Dates: during 1990-1999
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...reality is that almost all of the angiogenesis inhibitors have been found to be generic, not to induce drug resistance, to have low toxicity, et cetera, in animals," he adds. "This was first shown with TNP-470 many years...
...Ingber himself who, as a post-doctoral fellow, discovered the drug TNP-470, the first angiogenesis inhibitor from Folkman's lab to enter human clinical trials...
...contrast to newly discovered, highly publicized proteins like endostatin, Ingber says, TNP-470 has actually already been tested in humans in clinical trials conducted since 1992. In April 1998, the first complete tumor remission in a human using this drug was published as a case report in New England Journal of Medicine, and the drug will likely be entering Phase III trials very soon...
...addition, "many of the drugs which are in clinical trials and which the media has not focused on, also were a direct product of Folkman's work," Ingber says, citing TNP-470 and thalidomide as examples...
...high in fat and cholesterol, then measured the plaque buildup on the walls of each aorta, the large artery that carries blood from the heart to the rest of the body. Meanwhile, they injected one group of mice with endostatin, another with a different blood-vessel inhibitor called TNP-470 and a control group with an inert saline solution. Twenty weeks later the researchers again measured plaque in the mouse aortas. The results were startling: the endostatin group averaged 85% less plaque buildup and the TNP-470 group 70% less than those in the control group...