Word: tnp
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...reality is that almost all of the angiogenesis inhibitors have been found to be generic, not to induce drug resistance, to have low toxicity, et cetera, in animals," he adds. "This was first shown with TNP-470 many years...
...high in fat and cholesterol, then measured the plaque buildup on the walls of each aorta, the large artery that carries blood from the heart to the rest of the body. Meanwhile, they injected one group of mice with endostatin, another with a different blood-vessel inhibitor called TNP-470 and a control group with an inert saline solution. Twenty weeks later the researchers again measured plaque in the mouse aortas. The results were startling: the endostatin group averaged 85% less plaque buildup and the TNP-470 group 70% less than those in the control group...
However, according to Moulton, another drug tested in Folkman's lab, TNP_470, has similar effects as endstain on retarding plaque buildup and is being used in human trials. Moluton said she is interested in continuing research on heart disease to investigate the mechasnism behind the success of endostain and TNP...
About 10 years ago, the first inhibitor was discovered. Clinical trials began in 1992 to establish the use of the inhibitor--TNP-470--as a cancer drug, largely as an adjunct after chemotherapy...
...Tumor growth could be slowed significantly, but not reversed [using TNP-470]," Folkman said. "Nevertheless, for the first time, there was no drug resistance...