Word: toolan
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Dates: during 1950-1959
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...Sloan-Kettering Institute's Dr. Helene W. Toolan reported the first success with rats and rabbits. She took skin from embryos in the first third of gestation, found that it made a permanent graft on 45% of unrelated adults, grew a good crop of hair. Memorial Hospital's Plastic Surgeon Reuven K. Snyderman applied the technique to cancer patients and burn victims. From human embryos lost (from spontaneous or therapeutic abortion) during the first 4½ months of pregnancy he took skin grafts for eight patients. Four failed to take, probably because of infection, Dr. Snyderman suggested...
...Human cancer will grow in laboratory rats if they have been pretreated with cortisone or X rays. Dr. Helene W. Toolan left some rats untreated, planted human cancer tissue in them and a week later took blood and tissue specimens from the animals. Fresh pieces of cancer tissue were immersed in this material, then transplanted into pretreated rats. These implants failed to grow. The cancer had been neutralized by an immune mechanism in the blood of the first, untreated rats. ¶ Properdin, a chemical that occurs naturally in the blood, is one of the factors in immunity. Zymosan. a yeast...
...major handicap in cancer research has been the difficulty of growing human cancers in laboratory animals so that a whole arsenal of chemicals, viruses and antibiotics may be tested directly upon the human instead of the animal varieties of the disease. Dr. Helene Wallace Toolan of Manhattan's Memorial Center reported that during the last year she had found what seemed to be the answer: human cancers took hold readily and grew well in rats that had first been dosed with cortisone. The hope in it for humans: more human cancer tissue to experiment with safely...