Word: topoles
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...risk of heart problems in users of not just Vioxx but Celebrex and Bextra as well, and by FDA advisory panels that recommended stronger warnings for the whole class of pain relievers known as COX-2 inhibitors. "The cardiovascular problems appear to be a class effect," says Dr. Eric Topol, director of cardiovascular medicine at the Cleveland Clinic. "But the magnitude of risk does seem to differ from drug to drug." It's now up to the FDA to decide whether the dangers, which in some drugs start to appear only at high doses, warrant its strongest, black-box warning...
...like Vioxx is that they increase the risk of two very common ailments: heart attacks and strokes. It's much harder to tell, without careful statistical analyses, when common events become more common. "The [drug-approval] system was tested in ways it was never tested before," says Dr. Eric Topol, chairman of cardiovascular medicine at the Cleveland Clinic. "In an era of mass marketing, where data may show uncertainty and where the FDA has no real authority to take action, this class of drugs was set up to fail...
...other nuclear state has." Western diplomats responded to Putin's cryptic cock-a-doodle-doo with a polite shrug. The last they heard, the cold war was over. As arms specialists tried to guess what Putin meant, some experts pointed to a mobile version of the silo-based Topol-M intercontinental ballistic missile, which is expected to roll out next year. Others wondered if Russia was hyping a long-sought-after missile that can zigzag to avoid interception or one that can travel at five times the speed of sound. Both may be capable of slipping past Washington's national...
...financial ties to companies that make them. But even the NCEP says the best ways to lower cholesterol are to get more exercise, eat less saturated and trans fats, and maintain a healthy weight. "Patients often think, Since I'm taking a statin, I'm protected," says Dr. Eric Topol, a cardiologist at the Cleveland Clinic. But although statins can reduce the risk of a heart attack, they won't eliminate...
...explanations. Since the older drugs help prevent heart disease, the JAMA study might only be picking up the absence of a protective effect in the COX-2 inhibitors. Or the new painkillers might actually promote the creation of blood clots. Or both processes might be at work. The point, Topol says, is that "the cardiovascular effects of the [COX-2 inhibitors are] woefully understudied...