Word: toxicants
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Dates: during 2000-2009
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...Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences (NIEHS) announced they will jointly award the Harvard School of Public Health $7.8 million over the next five years to examine the effects of toxic mixed metals on children last week...
...Easy to make and hugely profitable (a "point," or 0.1 g, sells for about $35 in Australia but costs only about 70? to make), ice is as toxic to societies as it is to users. Addicts are prone to reckless criminality and extreme violence as well as paranoia and convulsions. Just as worrying, says Shaun Evans, law-enforcement adviser to the Pacific Islands Forum, ice has brought other crime in its wake: "In the past, organized criminals stuck to one commodity, like heroin or LSD. Now we have polycriminals. Anything that will make money, they will do it." Evans...
Jacobs immediately started the only treatment doctors had to offer--attacking the tumors with intensive chemotherapy and radiation to try to kill the malignant growths. For seven weeks, her body was bombarded with radiation twice a day and poisoned with toxic chemotherapy drugs once a week...
Jacobs is part of an exciting vanguard--the first wave of cancer patients who are benefiting from a more targeted, molecular-based assault on the disease. Old-fashioned chemotherapy and radiation treatments were blunt weapons that killed healthy cells along with malignant ones; the treatments were far too toxic for most patients to endure. By comparison, the new-generation drugs are precision-guided missiles that zero in on tumors with a minimum of collateral damage. Used in combination with advanced techniques for classifying tumors by their molecular signatures and screening patients by their DNA, the drugs are transforming cancer from...
...that the drugs will work. That's because no two patients are alike. Subtle differences in their genetic code often determine how well a cancer drug will be tolerated and how quickly it will be broken down in the body. Some people produce enzymes that can neutralize the more toxic side effects of anticancer drugs, while others either lack such agents or have genes that produce the opposite effect, making them more sensitive to the drug's adverse effects. Researchers at MGH, for example, found that changes in the gene coding for an enzyme involved in DNA repair can mean...