Word: toxicated
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Dates: during 1940-1949
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...name: Diasone) is the best drug yet used to treat guinea pigs newly infected with tuberculosis. It is a sulfa drug which Professor Raiziss says is even better than Promin, another diaminodiphenylsulfone derivative, hitherto the best anti-t.b. drug. Three good points about Diasone: it is only slightly toxic, therefore can be used in fairly large quantities with safety; it is as good as sulfanilamide in curing streptococcus infections in mice; it is almost as good as sulfadiazine in curing type II pneumonia. The big question: Will Diasone help human patients...
When only a quarter of the protein was left, he tested it for virus infectivity, found that it had almost exactly a quarter of the toxic strength of the original solution-strong evidence, he believes, that the virus and protein molecules are one & the same...
...Toxic reactions from the drugs are frequent-a survey of sulfas taken internally shows that some toxic reaction occurred in 29.8% of sulfapyridine cases, 11.8% of sulfathiazole and 7.7% of sulfadiazine. Most of these reactions are not dangerous, merely a nuisance (e.g., nausea, vomiting, dizziness, mild anemia, lack of appetite, tingling sensation), and do not interrupt treatment. But some rare reactions may prove fatal unless caught early. Even the less toxic sulfa derivatives can cause trouble: three cases at Johns Hopkins Hospital suffered not only kidney damage but brain injury from sulfathiazole; two majors in the Army Medical Corps last...
...Neither quinine nor atabrine will suppress all infections. Among British forces near Panafrica's stations, about 30% of those on 0.3 gr. of quinine hydrochloride daily, and 23% of those taking 0.4 gr. of atabrine dihydrochloride weekly, developed clinical malaria (incidentally, "no toxic effects from atabrine were noted"). Panafrica had to abandon Accra, a bad malaria spot on Africa's Gold Coast. In spite of quinine, in about two months 46 out of 284 men occupying partially screened quarters had malaria...
...Plasmochin, another synthetic, does not kill asexual forms of the protozoa unless given in toxic doses, is therefore not used for eradicating symptoms. But in very small amounts it kills all sexual forms, is therefore used to supplement quinine or atabrine to prevent convalescents from passing protozoa on to mosquitoes. Plasmochin is safe to give simultaneously with quinine, but some doctors believe it produces toxic effects if given along with atabrine, advise waiting a few days after atabrine before giving...