Word: toxicated
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Dates: during 1940-1949
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Sulfapyridine brings far better results than sulfanilamide, but it is a difficult drug for the body to absorb and excrete, also causes a "very troublesome nausea." At present it has a narrow range of use, for sulfathiazole is equally effective, less toxic...
Sulfadiazine seems to be "rather non-toxic." It is "very promising at the moment and may prove to be the next step in the sulfonamide ladder." (Last week Perrin Long of Johns Hopkins, top-flight sulfa specialist, announced that this drug will be on the market by early fall. Said he: "I have good reason to believe it will supplant all sulfa drugs now being used...
...doctors first tried neoarsphenamine in their Murphy drip, but found it "too dangerous." Mapharsen, which is less toxic, was discarded by Ehrlich because it was too unstable. But modern chemists have "set" the drug...
...patients in the early stages of arthritis he gives a course of twelve weekly injections of a gold-sulfur compound. Injections are made into a muscle. Doses are too small to bring toxic results: the first injection is only ten milligrams, the second 50, the next ten 100. During the first three weeks, said Dr. Dawson, a patient may feel "much worse." But in the second half of the course he shows "marked improvement." After the twelfth dose he is given a month's rest before another course of injections...