Word: toxicated
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Dates: during 1940-1949
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Tibione is more toxic than streptomycin or P.A.S., but most patients suffer only loss of appetite, malaise, and skin eruptions which look like measles. These side effects soon pass, and Tibione (unlike streptomycin) can be given to a patient for months or even years. It is taken in tablet form, usually four times a day. Because the drug was developed during the war, the German patents are no good and any U.S. manufacturer can make it. A few patients in U.S. hospitals have been dosed with Tibione; it will soon be tried on thousands...
...Favor? Drug manufacturers, catering to the hopeful eagerness of snifflers, have been trying to find an anti-histaminic which would not cause side effects. The Nepera Chemical Co. of Yonkers, N.Y. came close with neohetramine. Several doctors reported it less toxic, and toxic to fewer people, than other drugs in the same family. In September the Food & Drug Administration, satisfied that the average customer would not be upset by the recommended dosage, authorized its sale over the counter...
...developed by Ehrlich, proved to be effective against syphilis. Much later, in 1935, came the sulfa drugs, the medical wonders of their day. But none of the chemical "magic bullets" was effective against more than a few disease organisms, and all of them were apt to have dangerous toxic effects on human tissues...
Chiefly concerned are isotopes of elements which the thyroid, especially in cases of toxic goiter, has the property of absorbing and concentrating at the afflicted portion of the gland. This process enables the radiation emitted by the radioactive isotopes to destroy harmful growths. Other elements which do not become concentrated in the body as iodine does, may be used in research on body chemistry, since by their effect on a Geiger counter, their progress through the body may be traced--thus they are termed "tracer elements...
What could be done about malarial mosquitoes which escape DDT campaigns? Four war-born drugs help their victims, the conference was told: 1) chloroquine, more active than quinine or atabrine, and much less toxic; 2) pentaquine, which has reduced the relapse rate in the vivax form of malaria from 98% to 25%; 3) iso-pentaquine, a variant of pentaquine, so far tried on only 100 cases; 4) Paludrine, which controls vivax malaria with a single dose...