Word: toxication
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Dates: during 1980-1989
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...male lover. Durang, who has made wondrous mock of such sacred institutions as Roman Catholicism, child rearing and the Hollywood musical, might have considered confronting the last taboo by updating his satire to the Age of AIDS. But no. The play has come to the screen inert and toxic, a poisonous time capsule...
...About two weeks ago I got an exterminator to fumigate the gameroom, and because the gas fumes he used were toxic, I had to shut the gameroom from 12 noon to 6 p.m. I put up big signs warning people to stay out, but when I went down there at two in the afternoon, about five people were in the room playing away. The exterminator hadn't locked the gameroom door and they had come in and couldn't have cared less about poisonous gas. Well, we all have our priorities," Miller says...
While Spencer's discovery cannot directly explain the cases of the San Francisco 49ers or the Ohio schoolteachers, it does lend credence to the notion that something toxic in diet or environment can later trigger ALS. Indeed, over the years, a befuddling array of culprits has been suggested. They include infection with poliovirus, exposure to heavy metals, employment in the plastics industry and a history of traumatic injuries...
Unfortunately, AZT is not a cure and has a number of serious drawbacks. It must be taken every four hours around the clock to be effective, and can cause severe bone-marrow damage and anemia in some patients. "It's not an answer, and it's very toxic," says Polk, of Johns Hopkins. "Probably half of our patients on AZT will require weekly or bimonthly blood transfusions...
Perhaps the most promising of the dozens of other AIDS drugs under development is dideoxycytidine (DDC), which belongs to the same category of drugs as AZT. Like AZT, it works by interfering with viral reproduction, but researchers hope it will prove to be less toxic. Hoffmann-La Roche expects to receive a license to manufacture the drug within the next few months...