Word: toxication
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...looked for. They stopped deadly streptococci, even cured pneumonia. But the more sulfa drugs were used, the clearer it became that they 1) sometimes delayed healing by irritating wound walls, 2) did not work well in serum or pus. When used internally, they can cause severe, sometimes fatal, toxic reactions (TIME...
...name: Diasone) is the best drug yet used to treat guinea pigs newly infected with tuberculosis. It is a sulfa drug which Professor Raiziss says is even better than Promin, another diaminodiphenylsulfone derivative, hitherto the best anti-t.b. drug. Three good points about Diasone: it is only slightly toxic, therefore can be used in fairly large quantities with safety; it is as good as sulfanilamide in curing streptococcus infections in mice; it is almost as good as sulfadiazine in curing type II pneumonia. The big question: Will Diasone help human patients...
When only a quarter of the protein was left, he tested it for virus infectivity, found that it had almost exactly a quarter of the toxic strength of the original solution-strong evidence, he believes, that the virus and protein molecules are one & the same...
...Toxic reactions from the drugs are frequent-a survey of sulfas taken internally shows that some toxic reaction occurred in 29.8% of sulfapyridine cases, 11.8% of sulfathiazole and 7.7% of sulfadiazine. Most of these reactions are not dangerous, merely a nuisance (e.g., nausea, vomiting, dizziness, mild anemia, lack of appetite, tingling sensation), and do not interrupt treatment. But some rare reactions may prove fatal unless caught early. Even the less toxic sulfa derivatives can cause trouble: three cases at Johns Hopkins Hospital suffered not only kidney damage but brain injury from sulfathiazole; two majors in the Army Medical Corps last...
...Neither quinine nor atabrine will suppress all infections. Among British forces near Panafrica's stations, about 30% of those on 0.3 gr. of quinine hydrochloride daily, and 23% of those taking 0.4 gr. of atabrine dihydrochloride weekly, developed clinical malaria (incidentally, "no toxic effects from atabrine were noted"). Panafrica had to abandon Accra, a bad malaria spot on Africa's Gold Coast. In spite of quinine, in about two months 46 out of 284 men occupying partially screened quarters had malaria...