Word: toxin
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Dates: during 2000-2009
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...picture question was how do proteins evolve new functions? How do you go from a harmless digestive enzyme into something that’s a toxin?” said Hopi Hoekstra, an associate professor of natural sciences and one of the authors of the study. “We were particularly interested in the molecular changes that supercharge the enzyme...
Shrews, along with platypuses, are among the few venomous mammals, and they produce a toxin in modified salivary glands that enters their prey’s circulatory system when they bite, Hoekstra explained...
...toxin is an enzyme, a type of protein that accelerates the rate of chemical reactions by bringing reactants together in the enzyme’s active site...
When lead author Yael T. Aminetzach, a postdoctoral fellow in OEB, compared the toxin to a nontoxic counterpart, she found that the molecular changes occurred in active site of the enzyme. While the toxins from the lizard and the shrew are distinct, the overall trend of changes turned out to be the same...
Iannacone said he found out that sodium azide was the toxin along with three other victims last Thursday in a meeting with HMS officials. The other two victims were out of the country, he said...