Word: toxins
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Dates: during 1960-1969
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...watchdogs and spoken of in whispers as "the most secret chemical-warfare establishment in this hemisphere." The chief security officer has been murdered. Dr. Baxter is missing. Dr. Oster is a marked man. Worst of all, some crucial flasks have been pilfered from E Lab. Several contain enough botulinus toxin to wipe out the entire population of Los Angeles. One flask, warns Research Scientist Hoffman (Richard Basehart) is brimful of the "satan bug," a biological doomsday weapon that can launch death on a global scale. In this unpersuasive sci-fi thriller directed by John Sturges (Bad Day at Black Rock...
...chronicle with great anger and great love-anger for the stupidity and venality of the powerful, love for the weakness of the weak. In their testimony, the town fathers incriminate themselves: the rich doctor objects that Marcy is taking money from the purses of honest physicians with her free toxin-antitoxin shots; the minister pompously complains of Marcy's interfering when she tells of tubercular prisoners in the penitentiary. The voices of the poor exalt Marcy: it is recalled that she went more than 20 miles through waist-deep snow to tend the dying child of a miner when...
...addition, he had conducted research on cytochromes, iron-containing enzymes which are closely related to hemoglobin. Cytochromes fulfill an important function in the oxidative processes of metabolism in many organisms. Since diphtherial cytochrome is probably a derivative of coproporphyrin, the dual inhibiting effect of iron suggested that the toxin operates by "impersonating" cytochrome...
...synthesis would produce readily detectable effects. The Cecropia silk worm satisfied the requirement. During both the caterpillar phase and the period of adult development Cecropia produces substantial quantities of cytochromes. In the dormant pupa stage, though, the enzymes occur in only trace amounts. By showing that resistance to diphtheria toxin in the pupa stage is much greater than during other phases, Pappenheimer furnished compelling evidence for his theory...
...study the broad topic of oxidative phosphorylation. Of particular interest to him is ATP, the major energy-storing compound of the living cell. ATP is involved in the cytochrome oxidizing processes mentioned above. Thus, Pappenheimer's work at Amsterdam will probably yield additional information concerning his old friend, diphtheria toxin...