Word: trachea
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Dates: during 2000-2009
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...Barcelona Stem Cell-ebration European physicians have announced the success of a breakthrough procedure in which a woman's windpipe was rebuilt using her own stem cells. The operation, performed on 30-year-old Claudia Castillo this past June, seeded a stripped-down segment of a donor's trachea with stem cells from Castillo's bone marrow, ensuring a perfect tissue match and reducing the likelihood of transplant rejection. The procedure has been championed as a milestone that could pave the way for radical improvements in organ transplants and the treatment of serious diseases...
...revolutionary technique consisted of scientists creating a hybrid of donor tissue combined with tissue generated from Sánchez's stem cells, which were drawn from her bone marrow. They took a donor trachea, stripped it of the cells that would cause rejection, and replaced them with Sánchez's own cells. The team of researchers was composed of scientists from the University of Barcelona, Britain's University of Bristol, and, in Italy, the University of Padua and Milan's Polytechnic. (See TIME's Pictures of the Week...
...Doctors tend not to recommend trachea transplants because the windpipe is one of the body's organs most prone to rejection. But because of Sánchez's unique situation - she was young and had a rare kind of tracheal damage - Spanish medical authorities granted special permission to Macchiarini and his team to go ahead with an experimental treatment...
...foreign that enters the body, including transplanted organs. That is why powerful and sometimes life-threatening drugs that suppress the immune system have always been imperative to prevent the rejection of new organs. That is, until now: the British medical journal The Lancet today lays out the first successful trachea transplant, which was also - and more importantly - the first tissue transplant to use stem cells and thus do away with immunosuppressive therapy...
...Claudia Lorena Castillo Sánchez, a 30-year-old Colombian mother of two who lives in Barcelona. A cough she developed in 2004 was later diagnosed as tuberculosis, and by March of this year, her condition worsened to the point where one bronchus - the extension of the trachea that connects to the lung itself - was blocked. The only possible conventional treatment was to remove one of her lungs, a procedure that would have dramatically impaired her quality of life...