Word: trastuzumab
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...That proved far too strong a claim, but monoclonal antibodies have finally begun to live up to more modest expectations. Rituximab was the first, but just a year later, the same approach led to trastuzumab, a drug that keeps growth factors from feeding certain kinds of breast-cancer cells. Such targeted treatments are effective only when the appropriate target exists. Trastuzumab latches onto a receptor known as HER2, which is abnormally abundant in only about 30% of breast-cancer tumors. A biopsy can tell doctors whether a patient is likely to respond to trastuzumab, but they'd hoped to find...
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