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Meanwhile, clinical and molecular researchers are launching a biological attack on the virus. Their objective: the development of vaccines to prevent its spread and drugs to treat those already infected. But the AIDS virus is a formidable adversary. Because it can reproduce so rapidly, says Harvard's Haseltine, it can mutate frequently, changing its outer coat (the essential ingredient in making a vaccine) 100 to 1,000 times as fast as quick-changing flu viruses. As a result, he says, "trying to develop a vaccine for AIDS is like trying to hit a rapidly moving target." Scientists are now searching...

Author: /time Magazine | Title: AIDS: A Growing Threat | 4/18/2005 | See Source »

...reproduction of the AIDS virus at least temporarily. But they produce debilitating side effects, like kidney damage, which make them unsuitable for prolonged treatment. Among these drugs are HPA-23, a compound developed at the Pasteur Institute in Paris, where Rock Hudson sought treatment; Suramin, originally used to treat such parasitic disorders as African sleeping sickness; and Foscarnet, a drug being tested in Sweden and Canada...

Author: /time Magazine | Title: AIDS: A Growing Threat | 4/18/2005 | See Source »

...pervasive that a hush quickly fell over the room and exploration of the options was inhibited. When Japan was issued a warning from Potsdam a month later, no explicit mention was made of either the Bomb or the Emperor. Radio Tokyo broadcast that the Japanese government would treat the warning with "silent contempt." On the island of Tinian that day, a 300-lb. lead cylinder with a core of enriched uranium was being transferred to the headquarters of Colonel Paul Tibbets' 509th Composite Group...

Author: /time Magazine | Title: Essay: Why Did We Drop the Bomb? | 4/18/2005 | See Source »

...genetic engineering companies are out to prove that they can work the same magic in the marketplace, turning those wonder drugs into profitmakers. Last week Genentech, an industry leader based in south San Francisco, began selling its first drug product for humans: Protropin, a growth hormone used to treat dwarfism in children. Genentech had previously developed Humulin, a synthetic insulin, but licensed it to an established pharmaceutical company, Eli Lilly, which put the drug on the market. Protropin, which is expected to generate annual sales of $40 million, is the first human drug that a new biotech company has tried...

Author: /time Magazine | Title: Going for the Gene Green | 4/18/2005 | See Source »

...dugout vibrating; something was in the Cards," Tudor kept yawning, "It's just another ball game." After Royals Lefthander Danny Jackson held St. Louis off in the 6-1 fifth game, when a close call at the plate caused Manager Whitey Herzog to mutter a few favorite epithets, the treat of a Tudor-Saberhagen showdown in a seventh game began to come into focus. All that required was a happier destiny for old Leibrandt in Game 6: a preposterous ninth-inning comeback, 2-1, topped by Dane Iorg's pinch...

Author: /time Magazine | Title: Sport: A Gracious War Between the State | 4/18/2005 | See Source »

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