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...substantial portion of drugs taken orally, in pill or liquid form, is lost to digestive processes and removed by the liver, and what remains can irritate the intestinal tract. Enter transdermal patches. First designed to treat motion sickness, they slowly deliver drugs through the skin from a reservoir within the patch, and are being used increasingly to treat hypertension, angina and other disorders. So far, the patches are limited to carrying small-molecule drugs that can diffuse through the skin. But several teams are experimenting with electrical or ultrasonic devices that can also push larger-molecule drugs through the skin...

Author: /time Magazine | Title: Beyond Needles And Pills | 1/15/2001 | See Source »

...body. Ailments as diverse as psoriasis, multiple sclerosis and Type I diabetes are all caused by an immune system run amuck. No one knows what initiates any of these chronic diseases or how they might be cured, but researchers have lately made significant headway in developing drugs to treat them--drugs that arguably represent the first substantial advancement in the field in 50 years...

Author: /time Magazine | Title: The Hunt For Cures: Autoimmune Diseases | 1/15/2001 | See Source »

Most of these drugs are genetically engineered biological molecules, and the majority are designed to treat rheumatoid arthritis and its close clinical relative, lupus. Like many other autoimmune diseases, both disorders strike women disproportionately. In RA, the immune system attacks the joints and eventually weakens the bones, causing excruciating pain, fatigue and daily bouts of fever. With lupus, the attack is far more generalized, affecting blood vessels, joints, skin and several internal organs. In severe cases, it can be lethal...

Author: /time Magazine | Title: The Hunt For Cures: Autoimmune Diseases | 1/15/2001 | See Source »

...clearly too soon to declare victory in the war on cancer, since 9 out of 10 new treatments will fail clinical trials. But doctors who treat the disease are experiencing a surge of optimism the likes of which they have never felt before. "It's no longer spin the wheel, let's try this drug, maybe it will work," says Henry Friedman, a neuro-oncologist at Duke University Medical Center. "We're going to know why a drug is or isn't working." And given the nature of cancer and the scientists who study it, if one approach doesn...

Author: /time Magazine | Title: The Hunt For Cures: Cancer | 1/15/2001 | See Source »

...likely bypass any future heart attacks. Over the past five to 10 years, however, doctors have come to realize that heart disease is more complicated than that. They're not by any means ready to abandon surgery, but now they rely more heavily on different types of drugs to treat both the long-term and short-term effects of heart disease...

Author: /time Magazine | Title: The Hunt For Cures: Heart Disease | 1/15/2001 | See Source »

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