Word: trialing
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Dates: during 2000-2009
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...Mari Kitahata, at the University of Washington, reports in the New England Journal of Medicine that HIV-positive patients enrolled in a nine-year study reduced their risk of dying as much as 94% by the trial's end if they began ART earlier, compared with patients who deferred treatment. "Our study adds to the weight of evidence accumulating that the balance between the potential benefit in survival of initiating therapy earlier outweighs the potential deleterious effects," says Kitahata, referring to concerns over the drugs' toxicity and possible long-term side effects...
...None of these guidelines have been supported by the gold standard of medical evidence, the randomized controlled trial. And as convincing and as large as the current study is, Fauci notes that it too lacks this scientific imprimatur. In Kitahata's study, researchers followed patients as they and their doctors made their own decisions about when they would begin drug therapy. Those who chose to start early - before their CD4 counts reached 350 cells or 500 cells, for instance - may have simply been more health-conscious overall and therefore less likely to die, which could have confounded the study...
More change might flow from a landmark trial underway in Istanbul. The case pits the state against a shadowy ultra-right-wing network allegedly led by retired generals. Prosecutors accuse the group of staging bomb attacks and assassinations in a bid to overthrow the ruling Justice and Development Party and create a pretext for military rule. Turkey is no stranger to coups - the military has stepped in to push the government this way or that three times in as many decades. As recently as 2007, a veiled threat prompted early elections...
...trial is the first time a coup plot has landed high-ranking military officials in court. The 40 soldiers now being held include a retired general and colonel believed to have cofounded JITEM, a secretive military-intelligence unit which many Kurds suspect is responsible for most of the dirty work in the southeast, including the extrajudicial killings of dozens of Kurdish activists. The Ergenekon trial - the group named itself after a mythic central Asian valley Turks believe they come from - "is a milestone," says Nuserivan Elci, who represents some 50 families of the 'missing' in Silopi. "It's a historic...
Sporting geniuses such as Tiger Woods have an intuitive, almost artistic feel for golf; Harrington belongs to a breed of amateur scientists who use an agonizing process of trial and error to master their craft. "Padraig is the hardest worker I've ever coached, and the most curious," says Bob Torrance, Harrington's 77-year-old swing guru. "[Former great Ben] Hogan was similar, both struggled early in their career. Both learned long and hard, and both became great...