Word: trialing
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Dates: during 2000-2009
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...powerful idea, and there was some intriguing early evidence suggesting that something as simple as popping vitamin D might hold off the second biggest cancer killer among American women - breast cancer. So researchers were expecting to see positive results from the Women's Health Initiative (WHI), the first controlled trial of the effects of vitamin D on breast cancer...
...women participating in the WHI - a multiyear government trial investigating a range of women's health issues, from hormone therapy to heart disease, cancer and fracture risk - half were given 1,000 mg of calcium and 400s IU of vitamin D daily, while the other half were not. After seven years, 528 women in the supplement group and 546 women in the control group had developed invasive breast cancer, an equivalent rate, indicating no effect from the vitamin D. Earlier observational trials had found positive links between women's taking higher amounts of supplemental vitamin D and lower breast-cancer...
...million loss and to fire nearly all of his radio-station staff. Worse still, Gaydamak, supposedly the model for the title role in the movie The Lord of War (starring Nicolas Cage as an arms dealer in Africa), is one of 42 high-profile defendants on trial in France for illegally shipping weapons to Angola in the 1990s. Gaydamak chose not to attend those proceedings. (See pictures of Israel...
Although JUPITER (Justification for the Use of Statins in the Prevention: an Intervention Trial Evaluating Rosuvastatin) was designed to study inflammation, its findings also underscore the risk of high cholesterol. The study's statin group clearly benefited from reducing CRP, but they had also simultaneously lowered their LDL levels to nearly 50% below the government-prescribed target of 100 mg/dL. Experts say the JUPITER results may prompt serious rethinking of the current guidelines - an issue that health officials have already been debating in recent years. "I would not be surprised if, given these results, we determined that normal LDL should...
...study suggests that screening all patients for CRP (a $10 test) as well as for cholesterol and blood pressure would not be unwise, or perhaps the test should be used for patients with indeterminate heart-disease risk, who may derive benefit from taking a statin. Longer-term trials are still needed, however, to show whether the benefits of statins outweigh their potential side effects - the drugs are relatively benign, but they are known in rare cases to cause debilitating side effects such as muscle weakness (which forced Bayer to pull its version off the market in 2001). There...