Word: trialing
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Dates: during 2000-2009
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...hours a night), tall (5'10'), OCD ( I have to fold and organize all my underwear and I need to make my bed each morning no matter what) Hottest trait: Sometimes my eyes change color to match what I’m wearing Claim to Harvard fame: Mock Trial, Peer Health Exchange, KKG <3 Best part about becoming a sophomore: Living in Adams House with the best roomies ever Fastest way to your heart: Have manners, be a good dancer, and give me dark chocolate What you miss most from the ‘90s: My Spice Girls cassette
...than one additional primary psychiatric disorder besides depression. All patients with multiple comorbidities - along with anyone whose depression had lasted more than two years - were excluded. Once the authors crunched all the numbers, they found that only 22% of STAR*D patients met entry criteria for a conventional antidepressant trial...
...STAR*D patients were taking citalopram, an SSRI marketed in North America as Celexa. Not surprisingly, those who met standard inclusion criteria for a clinical trial had significantly better outcomes on the drug. In the efficacy group, 52% responded to Celexa vs. 40% of the nonefficacy group. Patients in the latter group also took longer to respond and had to be readmitted to psychiatric settings more often. "Thus," the authors conclude, "current efficacy trials suggest a more optimistic outcome than is likely in practice, and the duration of adequate treatment suggested by data from efficacy trials may be too short...
...smaller 2002 study that arrived at similar results: in that paper, published in the American Journal of Psychiatry, Dr. Mark Zimmerman of Brown University and his colleagues found that of 315 patients with major depressive disorder who sought care, only 29, or 9.2%, met typical criteria for an efficacy trial. Similarly, psychologist Ronald Kessler of Harvard co-authored a 2003 paper in the Journal of the American Medical Association that concluded that most "real world" patients with major depression would be excluded from clinical trials because of comorbidities...
...quite lived up to their promise. But the University of Pittsburgh's Wisniewski, the lead author of the new study, cautions against interpreting the results as an indictment against greedy drug companies eager to exclude difficult patients in order to show better results. "If the population in a [clinical] trial were more representative, that would come at a cost," he says. Researchers expect a certain number of bad reactions during clinical trials; some of these reactions can cause serious medical problems. If patients enter a trial with multiple complications - if they are, say, not only depressed, but also cocaine-addicted...