Word: triggered
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Dates: during 1990-1999
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Still, there may well be a market for a good cold-decoy drug. Parents, for example, could take a whiff of BIRR 4 whenever their children come home from school with a cold. So could patients with severe asthma or emphysema, for whom colds can sometimes trigger a life-threatening battle for air. "It's a huge challenge to find a way to prevent colds," says Dr. Robert Couch, professor of microbiology at the Baylor College of Medicine in Houston. But think of the glory--and the prizes--for the scientist who finally does...
...victim was a woman in her late 60s or early 70s who, in despair, had pointed a pistol at her chest and pulled the trigger. As she lay in the emergency room of a small hospital in California's Central Valley, her condition presented no great medical challenge; it was fairly straightforward compared with many of the messy youth shootings that confront E.R. doctors nowadays. Yet the woman's attempted suicide proved to be an epiphany for the young physician who attended her. It not only altered his life and career but also would affect countless other victims of gunshot...
...humans. Until recently, animal testing and clinical trials of a single drug required an average 12 years of research and cost up to $300 million. But initial screening can now be done in a matter of days without using animals. Molecular biologists are able to isolate enzymes that can trigger human diseases, then expose those enzymes to a plant's chemical compounds. If a plant extract blocks the action of a particular enzyme--say, one that promotes a skin inflammation--they know the plant has drug potential. By extracting specific chemicals from the leaves, roots or bark with a series...
...last week it became startlingly clear that monkeying with the chemistry of the human mind can trigger problems much more serious than a dull sex life. Just 1 1/2 years after it approved Redux for treatment of obesity, the FDA issued a warning advising patients to stop taking it and its close chemical cousin fenfluramine immediately. At the same time, the drugs' manufacturers and distributors, Wyeth-Ayerst Laboratories, told physicians to stop prescribing them and took the dramatic step of pulling both medications from the market. The reason for such haste: new evidence had revealed that as many...
...first, the effects of serotonin seemed confined to the body alone: it was found to trigger contractions in the muscles and intestines and to regulate blood pressure by forcing blood vessels to constrict. But experiments at the National Institutes of Health in the 1950s revealed that compounds that depressed serotonin levels depressed patients as well. Not long after, researchers found two more clues to the serotonin-depression connection. The first was that reserpine, an anti-blood-pressure medicine that depresses serotonin levels, can sometimes trigger depression. The second came from iproniazid, originally developed as an anti-tuberculosis agent. The medicine...