Word: triparanol
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...loss of her husband's sexual potency, even though the state's law permits a husband to recover for the "loss of his wife's consortium."Mrs. Howard E. Krohn of Nashville had filed a $250,000 damage suit against the makers of the drug triparanol on the ground that it had rendered her husband impotent. The court ruled that in Tennessee an irate wife is entitled to her day in court only if she has suffered a personal attack, such as slanderous gossip, or an attack upon her marriage, as in alienation of affection. The difference...
Even after the most exhaustive tests, unexpected and harmful side effects of a new drug are sometimes discovered only after the drug has been put on the market. What bothered the Food and Drug Administration about the synthetic hormone substitute, triparanol, was that some of its harmful effects had been clearly indicated in advance...
Sold by Cincinnati's William S. Merrell Co. under the trade name MER/29, triparanol was supposed to lower the level of cholesterol in the blood and, presumably, reduce the risk of heart attacks. But too many people who took the drug later went bald, became impotent, or went blind from an unusual form of cataract. In applying for approval of MER/29, said FDA, Merrell improperly withheld information already in its files that triparanol had caused cataracts in animals...
Though it was perhaps the most widely used, triparanol was only one of several drugs recently taken off the market. The incident underscored a warning by a committee of doctors in their outspoken Medical Letter on new drugs: "Statements that a new drug has few, mild or no side effects should be ignored...
Even without triparanol, men who have had heart attacks and are threatened with others can still have their cholesterol lowered by a drug - provided they are willing to put up with breast enlargement, loss of potency and other side effects from female sex hormones. Figuring that heart disease sufferers would not mind such symptoms if they also developed one more aspect of femininity - relative immunity from heart attacks until late in life - Chicago's Dr. Jeremiah Stamler and fellow researchers treated a group of patients with Premarin, a combination of estrogenic hormones...