Word: trophics
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DIED. VIKTOR HAMBURGER, 100, leading experimental embryologist who parsed out the intricate workings of the developing nervous system; in St. Louis, Mo. Hamburger was collaborating with two other scientists in 1954 when his lab isolated the first trophic factor--chemicals that influence cell survival and help govern growth. Though Hamburger received many awards for his discoveries, he was overlooked by the Nobel committee, which honored his colleagues...
Just as important as protecting healthy neurons is repairing or replacing nerve cells that have been damaged. The body produces a whole bath of trophic--or growth--factors that help cells develop. If the brains of Parkinson's patients could be fortified with additional trophic doses, many scientists believe, damaged neurons might be reawakened or repaired. While there is some thought in the medical community about engineering genes to churn out the substances, the pharmaceutical industry is taking a more direct approach...
Currently, Guilford Pharmaceuticals in Baltimore, Md., and Amgen in Thousand Oaks, Calif., are collaborating on a synthetic neurotrophic compound that can be taken orally and then travels to the brain, where it bonds with proteins in dopamine neurons. The tricky part is that most trophic molecules are too big to move across the miniscule blood vessels in the brain, so Guilford and Amgen are working on a smaller one that can get where it needs to go. The progress so far is promising. "We're in Phase 2 human trials now," says Dr. Craig Smith, president of Guilford. "Although...
Just as important as protecting healthy neurons is repairing or replacing nerve cells that have already been damaged. The body produces a whole bath of trophic-or growth-factors, that help neurons and other cells develop. If the brains of Parkinson’s patients could be fortified with additional trophic doses, many scientists believe, damaged neurons might be reawakened or repaired. While there is some thought in the medical community about engineering genes to churn out the substances, the pharmaceutical industry is taking a more direct approach...
Currently, Guilford Pharmaceuticals in Baltimore and Amgen in Thousand Oaks, Calif., are collaborating on a synthetic neurotrophic compound that can be taken orally and then travel to the brain, where it bonds with proteins in dopamine neurons. The tricky part is that most trophic molecules are too big to cross the blood-brain barrier, so Guilford and Amgen are working on a smaller one that can get where it needs to go. The progress so far is promising. "We’re in phase two human trials and the study is going very well," says Dr. Craig Smith...