Word: tsai
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Dates: during 1990-1999
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...form of mutant mouse engineered by Tsai and her colleagues at HMS is starting to unravel what is considered to be one of the greatest enigmas in biology...
...Tsai and her team have recently isolated a gene in mice, called p35, which appears to play an integral part in the formation of the cortex...
...elucidate the gene's effects, Tsai used a recently-developed technique which allows researchers to selectively create "knockout mice"--mutant mice who are lacking in a specific gene. The researchers can then study the effect the loss has on the mutants by recovering the excited gene for study...
...Tsai says the mice lacking the gene were "not as active," were uncoordinated and walked unsteadily. Although they were still fertile, the mothers "displayed nurturing defects...
When the mutants' brains were sectioned and inspected, Tsai found that "the cortex [was] pretty much messed...