Word: tsai
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When finished, the normal six layers which should be present in the cortex were absent and "the distribution of cells seemed random at first," Tsai says...
...mutation caused younger cells to stop and not pass the older neurons. A gradient of increasingly older neurons toward the outside of the cortex resulted, which, according to Tsai, "effectively inverted the pecking order of the cortex...
...elucidate the gene's effects, Tsai used a recently-developed technique which allows researchers to selectively create "knockout mice"--mutant mice who are lacking in a specific gene. The researchers can then study the effect the loss has on the mutants by recovering the excited gene for study...
...Tsai says the mice lacking the gene were "not as active," were uncoordinated and walked unsteadily. Although they were still fertile, the mothers "displayed nurturing defects...
When the mutants' brains were sectioned and inspected, Tsai found that "the cortex [was] pretty much messed...