Word: tuberculin
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...cancer. Dr. Edmund Klein of Roswell Park Memorial Institute in Buffalo, N.Y., who has already had some success treating skin cancer, tried a variation of the treatment on five women. The patients had all undergone breast surgery already and were suffering recurrences of cancer. Klein injected a serum containing tuberculin-a substance that rouses the body to counterattack-directly into the women's cancerous lesions. Then, as the cancers showed signs of healing, he switched from the painful shots to regular applications of a tuberculin skin cream. Most people at some time in their lives have had tuberculosis antibodies...
Patients must take the little white isoniazid pill three times a day with meals, for at least a year after their disease is arrested. Members of a TB victim's immediate family should also take isoniazid, especially youngsters with a positive tuberculin test reaction. The cost, never great, is now down to $1.50 per 100 pills for private patients; and health agencies, which distribute most of the pills free, can get them for as little...
During a tuberculosis survey of Milan in 1958, schoolchildren had been given scratches on both arms: one for the tuberculin test, the other for histoplasmosis. This disease, which is like TB in the variety of its effects-ranging from an undetectable, mild infection to fulminating and rapidly fatal cases-is caused by a fungus, Histoplasma capsulatum. Unrecognized until 50 years ago, histoplasmosis is still often mistaken for, and mistakenly treated as, TB. It is now known to be especially common in the mid-continent states. But Milan's infection rate turned out to be an astonishing 62%, contrasted with...
...apparent effectiveness is confirmed, airborne vaccination will have a cost advantage over multiple BCG punctures in the arm, because it requires far less vaccine. And Dr. Middlebrook believes that his method will interfere less with the standard tuberculin skin test for TB infection. Obscured results in this test have been a major factor in U.S. opposition to wide use of BCG, though the N.T.A. convention heard from Northwestern University's Dr. Guy Youmans last week about a cheap, simple blood test which may reinforce and partly replace the tuberculin test. Most important to Dr. Middlebrook is the simplicity...
...even a small contribution toward reducing TB is worthwhile, point out that the vaccine was shown in Britain to be 80% effective in cutting down TB among exposed adolescents, a rate comparable to that of most other vaccines now in general use. They feel that the value of the tuberculin test has been exaggerated, that X rays and sputum tests are more important and more reliable. BCG vaccine is not perfectly standardized, but the University of Illinois' Research Foundation has pioneered a freeze-drying process by which the vaccine probably can be shipped anywhere and stored as long...