Word: tumor
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Dates: during 1990-1999
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Unlike other cancers, lung cancer is extremely hard to detect in its earliest, most treatable stages. Even so, about 20% of lung-cancer patients are found to have a tumor whose biological characteristics and small size give them a good chance of being cured if the malignant growth is surgically removed...
Endostatin is the first of several anti-cancer drugs under evaluation which prevent angiogenesis, the growth of new blood vessels in the body. Doctors hope that, by stopping the growth of blood vessels around a cancerous tumor, the drug can shrink tumors and prevent the cancer from spreading...
...block the supply of oxygen to tumor cells, then that's an approach to controlling tumors," Corey said. "It's a very interesting scientific hypothesis. [Folkman] has been working in a pioneering way to test that...
Although endostatin might prevent blood vessels in the body other than those around a tumor from forming, Corey said normal adult tissue can remain healthy without angiogenesis. Only tumors would be adversely affected, he said...
...question were removed from the mice while they were in the embryonic stage, after in vitro fertilization. Once the mice were born, scientists injected massive amounts of malignant cells into the rodents. In each of the genetically altered mice, little or no blood flow was available to the tumor, and the tumors did not grow at their normal, aggressive rate - or they didn?t grow at all. While the technology in this study is new, the theory behind it is not. "The idea of starving tumors of their blood supply is one of the leading areas of research in cancer...