Word: tumorous
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...angiogenic, the tumors become very dangerous and potentially lethal [and grow aggressively,]" Folkman said. "The proteins which the tumor cells deploy to recruit the vascular endothelial cells began to be identified 12 years...
...Tumor growth could be slowed significantly, but not reversed [using TNP-470]," Folkman said. "Nevertheless, for the first time, there was no drug resistance...
About two years ago, it was discovered that tumor growth could be slowed almost completely by using normal proteins to signal the vascular endothelial cells which line blood vessels...
...first time, it became possible to shut off angiogenesis and cause [tumor] regression," Folkman said. "This was caused by a specific signal which only talks to endothelial cells...
...well known that some tumors suppress the growth of metastases," Folkman said. "Our question was [that] if tumor size is ultimately controlled by endothelial proliferation, could a primary tumor suppress growth of a distant metastasis by delivering an endothelial inhibitor to it through the circulation...