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...work combines the efforts of three top NIH scientists: Steven Rosenberg, an expert in cancer therapy, and W. French Anderson and R. Michael Blaese, two master gene manipulators. For several years Rosenberg has been developing a novel cancer treatment using a type of cancer-fighting cell called TILs (tumor-infiltrating lymphocytes). He removes TILs from cancer patients and clones large quantities of the cells in the laboratory. When this army of cells is reinjected into the patients, their tumors can shrink significantly. In one experiment with metastatic melanoma patients, 60% of them benefited from the therapy. But Rosenberg still needs...

Author: /time Magazine | Title: Science: Coming: A Historic Experiment | 2/13/1989 | See Source »

...upcoming experiment, Rosenberg plans to inject ten terminally ill patients with TILs carrying the marker. Periodically, he will remove bits of tumor from the subjects and douse the samples in neomycin. If some cells survive the dosing, he will know the TILs have reached the tumor...

Author: /time Magazine | Title: Science: Coming: A Historic Experiment | 2/13/1989 | See Source »

...test is only the beginning. The NIH researchers and others elsewhere are planning to transplant genes that could actually help people fight cancer and other diseases. For example, scientists hope to give patients genes that will enable their bodies to mass-produce such anticancer agents as interleukin-2 and tumor necrosis factor. Anderson believes the day is not far off when it will be possible to transplant a gene containing instructions for the manufacture of CD4, a substance that combats the AIDS virus. Ultimately, researchers think they may be able to conquer some hereditary diseases by replacing defective genes with...

Author: /time Magazine | Title: Science: Coming: A Historic Experiment | 2/13/1989 | See Source »

Then came a traumatic change in his life. Geffen developed a bladder tumor, which doctors removed and declared to be malignant. Believing that stress had contributed to the cancer, Geffen, then 33, decided to change his priorities. Canceling his subscriptions to Variety and Billboard, he began teaching business courses at Yale and UCLA, collecting art and investing in real estate. After four years in his new life, he consulted cancer specialists for a second opinion and found that the first diagnosis had been incorrect: he was fine...

Author: /time Magazine | Title: Little Shop of Winners | 12/12/1988 | See Source »

...Emperor's doctors diagnosed his condition as "obstructive jaundice" and said the bleeding was related to a swelling of the pancreas and an internal blockage for which the Emperor had undergone an intestinal-bypass operation a year ago. They acknowledged for the first time the presence of a tumor in the Emperor's pancreas. For four days, as he received a series of blood transfusions and was fed intravenously, his condition remained fairly stable, but then it began once again to deteriorate. In the meantime, Crown Prince Akihito, 54, was asked by the Cabinet to assume temporarily his father...

Author: /time Magazine | Title: Japan Vigil for a Failing Emperor | 10/3/1988 | See Source »

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