Word: tumors
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...Stanford last year a small trial using the dendritic-cell approach cleared two patients of lymphoma and reduced tumor size in two others. Trials elsewhere have produced mixed but still promising results. Researchers have found a way to increase massively the number of dendritic cells ordinarily found in the body, in the hope of amplifying the therapeutic effect. Lyerly and his colleagues achieve their results by infusing patients with their own dendritic cells--after the cells have been encouraged to grow and have been altered in a way that enables them to stimulate a more aggressive immune response...
Yesterday we at Dartboard were yanked out of our contented shells by shocking news: Darryl Strawberry has cancer. Strawberry, the 36-year-old New York Yankees' slugger, will this weekend undergo surgery to remove a cancerous tumor in his colon...
...Toronto, "we're targeting every element of this disease from start to finish." The new drug Arava, for example, created by the Kansas City, Mo., firm Hoechst Marion Roussel, stops white cells from reproducing. Enbrel, a genetically engineered medication from Seattle-based Immunex, works by sopping up a tumor-killing cytokine called tumor necrosis factor before it can issue its call for reinforcements. The COX-2 inhibitors target prostaglandin production, limiting pain and inflammation. And the blood-filtration device, invented at Cypress Bioscience of San Diego, strips the blood of proteins that tell white cells (erroneously) what tissues to attack...
...start with the more complicated case. Doctors have used tamoxifen, first of the so-called designer estrogens, to treat breast cancer for 25 years. In that time, they've learned that the drug works by starving tumors that feed on estrogen. But could tamoxifen also stop a tumor before it starts? Last spring U.S. researchers reported with great fanfare that tamoxifen can indeed decrease the risk of developing breast cancer as much...
Trouble is, Black 6 and kin often do their jobs too well. "Mice distort or exaggerate what you see in humans," says tumor biologist Robert Kerbel of Toronto's Sunnybrook Health Science Centre. Mouse tumors, which are usually planted just under the skin, grow much more rapidly than deep-seated human tumors. Also, as Nobel laureate J. Michael Bishop observes, too much breeding isn't always a good thing. In his labs at the University of California, San Francisco, he is genetically altering mice to provide better models for studying leukemia and neuroblastoma, the most common tumor in children under...