Word: tumors
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...University oncologist Bert Vogelstein, had endowed the quiescent cells with a protective device that the dividing ones lacked, in this case a normal copy of a gene that acts as a circuit breaker, shutting down growth. The scientists had found a way, at least in theory, to stop a tumor after it gets started...
...chief of New York City's Memorial Sloan-Kettering Cancer Center. "But the lid of the black box has been opened, and we can see the wheels turning inside." The "wheels" are genes that regulate growth. Some, called oncogenes, activate the process of cell division; others, known as tumor- suppressor genes, or anti-oncogenes, turn the process off. In their normal form, both kinds of genes, working together, enable the body to perform the critical function of replacing dead or defective cells. But slight alterations in the genetic material, whether inherited or caused by environmental insult, can provoke the rampant...
...both of them were beyond the reach of infamy. The 74-year- old Casey died of a brain tumor just before he was to face the Iran-contra committee. Presidential aide Michael Deaver wrote that the director thus became "the logical candidate to be fingered as the evil genius behind Iran- contra. The secrets would be buried with him. And the President would be protected...
...cancer of the mouth and throat were given large daily doses of the drug for 12 months. After as much as three years, only two (4%) of the subjects developed a new cancer. In contrast, among 50 patients who received a placebo, 12 (24%) were stricken by a second tumor...
Like the retrovirus used by Anderson, Rosenberg's delivery system has been made harmless and endowed by recombinant DNA techniques with a human gene. But this gene codes for tumor necrosis factor, a naturally occurring compound that attacks cancer cells. The altered viruses insert themselves and their piggyback gene into the genetic material of the TILs, which are then injected back into the bloodstream of the melanoma patients. If everything goes as planned, the activated TILs will home in on the tumors like guided missiles, attacking the cancerous cells and at the same time releasing the antitumor factor to help...