Word: tumors
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...years ago, a tumor was discovered on Paul LaPorte's spine. It was benign, but it caused a symptom that he kept a darker secret than he would have had the diagnosis been terminal cancer. The growth pressed on the nerves to his bladder, causing it to empty unexpectedly. Surgery seemed too risky, and LaPorte's life became consumed by the harrowing effort to hide his embarrassing condition. He quit jobs and refused advancement. "One employer wanted to promote me to a sales position that meant traveling all over Canada," recalls LaPorte, now 36 and a factory worker in Windsor...
...same ceremony, awards will go to National Institutes of Health physician Robert C. Gallo, chief of the tumor cell biology laboratory, and Luc Montagnier, professor of viral oncology at France's Pasteur Institute. The scientists are credited with isolating the AIDS virus...
...stressed. "There are things that work in mice that do not work in people." Still, some of the results published last week in the journal Science were compelling. For example, mice subjected to the new treatment proved to be immune to malignancies seeded by cells from the original tumor. And the NCI team has already isolated the same kind of powerful cancer-fighting cell in humans. "It's potentially very exciting," Rosenberg concedes. He believes the U.S. Food and Drug Administration will agree and approve the treatment for human trials within the next two months...
...treatment is a form of immunotherapy, an experimental technique that has been refined substantially in the past five years as an alternative to surgery, radiation or chemotherapy. Immunotherapy enhances the immune system's disease-fighting capabilities by using some of the body's own chemical agents -- the interferons, tumor-necrosis factor or interleukins, for example. Last year, in one of immunotherapy's most promising clinical trials to date, Rosenberg's team used the hormone-like substance interleukin-2 to turn certain white blood cells into cancer destroyers called lymphokine- activated killers. Reinjected into the bloodstream with more...
...treatment answers those problems and then some -- at least in mice. Rosenberg's team found potential guided-missile cells called T lymphocytes in tumor tissue removed from the mice. They minced the tumor, added IL-2, and soon a whole colony of the anticancer cells -- called tumor-infiltrating lymphocytes -- were thriving while the cancer cells were dying out. After 15 days, the researchers injected millions of TIL cells back into the mice. The cells, as if by instinct, sought out the tumors that had spread from the original cancer and attacked them. To keep the TIL cells vigorous and growing...