Word: tumors
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...national security itself, would be vulnerable if a grave illness were admitted. As John B. Moses and Wilbur Cross relate in the book Presidential Courage (W.W. Norton Co., 1980), many Presidents suffered, usually in silence and secrecy, from chronic and painful diseases. George Washington had a giant benign tumor in his leg and was the victim of rheumatism and repeated pneumonia. Andrew Jackson, famous for his stamina and courage, was described in a contemporary article in the Boston Medical School Journal as "a tottering scarecrow in deadly agony," a man in whom "the malaria, the dysentery, the osteomyelitis...
Most doctors classify colorectal cancers according to a scale developed by an English pathologist named Cuthbert Dukes in the 1930s. The Dukes scale uses the letter A to describe a malignant tumor that is confined to the colon's inner lining, B to characterize one that has spread beyond the inner lining but has not reached the lymph nodes, and C for one that has pierced the outer wall or begun to spread to the lymph nodes. Doctors also use these classifications to estimate patients' chances of survival. Patients with Dukes A tumors have a 90% chance of surviving five...
DIED. JOHNNIE COCHRAN, 67, savvy, media-friendly attorney renowned for his resplendent dress and seemingly effortless charm with juries; of an inoperable brain tumor diagnosed in 2003; at his home in Los Angeles. Born in Shreveport, La., a great-grandson of slaves, Cochran won recognition after suing police departments for abuse in the 1960s and proudly displayed copies of his plaintiffs' multimillion-dollar checks in his office. His fame crested in 1995 after his successful defense of O.J. Simpson, against seemingly overwhelming evidence, of charges that he murdered his ex-wife and her friend. Cochran's signature line, a reference...
Meanwhile, scientists at Vion Pharmaceuticals in New Haven, Conn., have been experimenting with another bacterium, salmonella, and another way of destroying a tumor from the inside out. Salmonella is a familiar but unwelcome interloper in kitchens and at picnics, thriving in uncooked meats and other food products such as eggs. Once in the blood, its surface coat can trigger septic shock, a hyperaggressive immune response that can lead to liver and kidney failure and a dangerous drop in blood pressure. Confined to a tumor, however, the bacterium could be a potent cancer killer. Like the measles virus, salmonella zeroes...
...need all those microbes if the bad-bug approach turns out to be as successful as early trials suggest. Like AIDS cocktails and cancer chemotherapies, microbe-based therapies may require a multidrug approach. For example, combining the modified clostridium bacterium, which attacks a tumor at its anaerobic core, with the altered measles virus, which destroys the periphery of the tumor, could be a potent new way to fight cancer. Add some radiation or chemotherapy to mop up any lingering cancer cells, and doctors could find themselves closing in on a cure...