Word: tumors
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...arms them with detailed instructions for finding their target cells and outfits them with specially designed protein keys to speed up entry. As far as he's concerned, those viruses are the good guys, since the cells they are attacking and destroying are cancer cells in a fast-growing tumor...
...strategy was championed by doctors treating allergies and infectious diseases. The idea was to expose patients to small quantities of partly disabled microbes to jump-start their immune system. But cancer researchers have taken the approach one step further, turning microbes into tiny Trojan horses that can sneak into tumor cells and destroy them from within. "There is a good probability that microbe approaches will be part of the arsenal of the future," says Kenneth Kinzler, a cancer researcher at Johns Hopkins Hospital's Kimmel Cancer Center who is working with the clostridium bacterium. "We're betting...
Forty years later, scientists know a lot more about genes and proteins and how to target microbes so that they home in on one particular kind of cell--a cancer of the ovary, for example, or a tumor in the throat. They have also learned to affix molecular tracking devices to a microbe to ensure that when let loose in the body, it doesn't deviate from its therapeutic mission...
...easily controlled with antibiotics or antiviral medications should something go awry. For his research, Russell likes the measles virus, in particular, the modified strain of the virus used for more than five decades in the measles vaccine. That weakened form has a special fondness for tumors, lured there by a protein expressed in copious quantities on the surface of malignant cells. As part of an ongoing trial in ovarian-cancer patients, Russell's colleague Dr. Eva Galanis constructed a measles virus that could also churn out a protein that can be picked up in the blood, allowing the investigators...
...Jackson in 2000, when the accuser was 10 and suffering from what was diagnosed as incurable leukemia. Surgeons removed his left kidney and spleen and a 16-lb. tumor. He was given large doses of chemotherapy, which doctors said would either save his life or kill him. The kid deserved a break. When he asked to meet his hero, Michael Jackson, it was arranged...