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When cancerous cells form a tumor and begin to grow uncontrollably, they need to induce the formation of new blood vessels to bring them oxygen and nutrients—a process known as angiogenesis. A team of researchers at Massachusetts General Hospital has discovered that the main effects of an angiogenesis inhibitor in treating glioblastoma, a severe kind of brain tumor, stem from the reduction of brain swelling, rather than any effect on tumor growth. In these tumors, blood vessels can be leaky, which causes swelling in the brain known as edema. This, in turn, can cause drowsiness, loss...

Author: By Alissa M D'gama, CRIMSON STAFF WRITER | Title: Tumor Treatment Reduces Swelling of Brain | 4/10/2009 | See Source »

...Prostate cancer, which kills 29,000 men in the U.S. each year, is a tenacious disease in advanced stages. The treatment of cancer that has metastasized beyond the prostate involves drugs that block male hormones, the androgens testosterone and dihydrotestosterone, which feed tumor growth. Antiandrogen drugs, like bicalutamide, work by binding to the androgen receptors on prostate-cancer cells, chemically preventing the hormones from interacting with the tumor. Over time, however, cancer cells become resistant to the drugs as the number of androgen receptors on the cells increases, and in a cruel twist, the drugs somehow begin to stimulate...

Author: /time Magazine | Title: Experimental Prostate-Cancer Drug Shows Promise | 4/8/2009 | See Source »

...Trouble in Ireland Michael Elliot's view that it will take a long time to drain the poison from Northern Ireland is very perceptive [March 23]. The latest outbreak of IRA violence is like a recurring tumor, the cause of which is a pernicious cancer in the Nationalist body politic, namely: our fixation with a "united Ireland." As long as we succumb to our animal territorial instinct and harbour this futile dream, every generation will produce some young hotheads prepared to use violence to achieve it. Of course, like Gerry Adams and Martin McGuinness et al, they will come...

Author: /time Magazine | Title: 10 Ways to Change the World | 4/2/2009 | See Source »

...Another, subtler problem can be the difference between what are known as surrogate outcomes and patient outcomes. A new drug or treatment may reliably lower cholesterol, say, or reduce the size of a tumor - these are surrogate outcomes - and the drug-maker would call that a success. But the ultimate goal of treatment isn't simply to give you lab results you can boast about, it's to make you feel better and live longer; those are the patient outcomes. Sometimes though, good surrogate outcomes don't lead to good patient outcomes. Hormone replacement therapy, for example, raises good cholesterol...

Author: /time Magazine | Title: How Not to Get Misled by Health Statistics | 3/25/2009 | See Source »

...said. Nominations for knighthood are submitted to the British Foreign Office in London, where the British Foreign Secretary reviews the suggestions and makes recommendations to the queen, Pickerill said. Ultimately the queen has the final say as to who will be honored. Kennedy, who was diagnosed with a brain tumor last May, received an honorary degree from Harvard in a special convocation ceremony in December. “On a local level, we’re delighted that the senator from the state we represent is being honored,” Pickerill said. Other notable Americans who have been named...

Author: By Lauren D. Kiel, CRIMSON STAFF WRITER | Title: Senator Ted Kennedy welcomed as a member of the Most Excellent Order of the British Empire | 3/5/2009 | See Source »

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