Word: tumors
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Both drugs have been dubbed "designer estrogens" because they block estrogen's ability to promote tumor growth in the breast while at the same time mimicking the hormone's salutary effects on the spine. (About 75% of all breast cancers are estrogen-sensitive.) But they can also trigger serious side effects, including potentially fatal blood clots. So the good news about designer estrogens must always be tempered with some heavy-duty caveats...
...Folkman--also director of the surgical research laboratory at the Children's Hospital Medical Research Center of HMS--who first hypothesized in the 1970s that cutting off a tumor's blood supply would essentially starve a tumor, potentially saving the lives of cancer patients...
...cancer patient whose tumor is not responding to conventional therapy can go into clinical trials of new drugs, but there are sometimes waiting lists and shortages," Folkman says. "Whenever lab discoveries come close to application, you have to be super-extra careful...because media coverage can increase expectations...
...contrast to newly discovered, highly publicized proteins like endostatin, Ingber says, TNP-470 has actually already been tested in humans in clinical trials conducted since 1992. In April 1998, the first complete tumor remission in a human using this drug was published as a case report in New England Journal of Medicine, and the drug will likely be entering Phase III trials very soon...
...media wants a silver bullet, but it is virtually impossible to obtain one, especially given how cancer trials are designed...using end-stage patients who have failed all other therapies with large tumor mass, et cetera," he says...