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Dates: during 2000-2009
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...ages 12 to 18 and asked them to fill out a questionnaire about their tendency to engage in behaviors such as driving without a license, having unprotected sex and using drugs. Then they had the kids undergo a relatively new kind of brain scan called diffusion tensor imaging, a type of magnetic resonance imaging that is used to look at dense tissues like white matter. After analyzing the scans, the authors found a strong correlation between how risky the students described their behavior to be and how sophisticated their white matter was. The more mature the look of the brain...
This week, scientists at the Harvard Stem Cell Institute (HSCI) reported the first success in generating new populations of insulin-producing cells using skin cells of Type 1 diabetes patients. The achievement involved the newer embryo-free technique for generating stem cells, and marked the first step toward building a treatment that could one day replace a patient's faulty insulin-making cells with healthy, functioning ones. (See the top 10 medical breakthroughs...
...experiment, published in the Proceedings of the National Academy of Sciences, also provided the first good model - in a petri dish - of how Type 1 diabetes develops, giving scientists a peek at what goes wrong in patients affected by the disease. Such knowledge could lead to not only new stem-cell-based treatments, but also novel drug therapies that might improve the symptoms of the disease. (Read "Study: Stem Cells May Reverse Type 1 Diabetes...
Douglas Melton, co-director of HSCI, and his team took skin cells from two Type 1 diabetes patients, exposed the cells to a cocktail of three genes that converted them back to an embryonic state - which are referred to as pluripotent stem cells - then instructed the newly reborn cells to grow into beta cells, the cells in the pancreas that secrete insulin. In Type 1 diabetes, these beta cells no longer work to break down the glucose that floods the body after each meal, leading to blood-sugar spikes that can damage the kidneys and heart...
While diabetes doctors generally agree that the first line of defense against Type 2 diabetes should always be exercise and diet, many recommend also using drugs. For its part, the American Diabetes Association advises patients with Type 2 diabetes to make appropriate lifestyle changes and to start a drug regimen immediately upon diagnosis. Dr. R. Paul Robertson, a spokesperson for the organization, says that for people with diabetes, "the goal should not be to avoid drugs. It is to do everything you can to keep your sugar levels down...