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ALAN DEMEURERS RECALLS IT VIVIDLY AS ONE BRIGHT moment in a succession of dark days. "I remember exactly where we were sitting," he says. His wife Christine had by then been found to have metastatic breast cancer and believed her only hope was to undergo a costly new kind of therapy that involves the harvest and retransplant of her own bone marrow--high-wire medicine occupying what one of her physicians calls "the twilight zone between promising and unproven treatments...
...also should allow them to use their values and where they're coming from to pick among the treatment options that are rational." He could not wholeheartedly recommend a transplant in her case, he says, but a transplant "was on the rational list." First, however, she had to undergo the initial chemotherapy to test the responsiveness of her cancer. Dr. Schinke, using drugs recommended by Dr. Glaspy, began the cycle...
...Gupta, reviewing his notes on the case, says Dr. McMillan agreed Christy was a candidate for a transplant but said she would first have to undergo several cycles of chemotherapy to demonstrate that her tumor would respond to the potent drugs used in bone-marrow therapy. In the deMeurerses' eyes, however, it was a deeply troubling encounter. Dr. McMillan declined even to describe what was involved in a bone-marrow transplant or give the family a tour of the Scripps facilities, according to Alan deMeurers and Christy's mother, Joyce Nesmith. "I believe he was told to send us away...
...week later, Christy, accompanied by her mother, returned to Dr. Gupta, whom they still viewed as a beacon of warmth. "There's lots of hope, lots of things to do," Nesmith recalls his saying. Christy, dissatisfied with her reception at Scripps and reluctant to undergo months of treatment away from home, wanted a referral for a second local evaluation, this time at UCLA. Dr. Gupta agreed to make such a recommendation in writing, says Nesmith. He told Christy and her mother to go somewhere for lunch and then come back; the letter would be ready...
...more than a year and some intense lobbying for Getty to win the right to become the first AIDS patient to receive a baboon bone-marrow transplant. He overcame the last bureaucratic hurdle in August, when the Food and Drug Administration agreed to allow Getty, and Getty alone, to undergo the procedure. Then in the fall, he developed potentially fatal pneumocystis pneumonia, which postponed the transplant until December...