Word: unproven
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Dates: during 1980-1989
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...brief interruptions. There was Jawaharlal Nehru, India's first Prime Minister and an early leader of the durable Congress Party, his daughter Indira Gandhi, and her son Rajiv. Such was the family's sway that when Indira was assassinated in 1984, the 40-year-old Rajiv, a reluctant and unproven politician, was rocketed into high office on the strength of one credential: his name...
...month ago, though, few people were predicting a smash. The movie's star, Kirstie Alley of TV's Cheers, was an unproven marquee draw. Its male leads, Travolta and George Segal, were long past their luster. Critics mostly dumped on the picture or ignored it. Savants figured, in fact, that it had about as much chance of being a hit as, say, a single sperm has of fertilizing...
...resign from Congress because of his 1985-1987 relationship with prostitute Steven L. Gobie. Frank has admitted that he paid Gobie and other male prostitutes for sex, hired Gobie as a personal assistant and then used his Congressional position to void some of Gobie's parking tickets. Still unproven are charges that Frank knew that Gobie was operating a prostitution ring out of his home...
Beginning in 1984, the FDA permitted the Syntex pharmaceutical firm to give doctors free ganciclovir, a drug used to treat eye infections that frequently blind AIDS patients, under a special program that allows "compassionate use" of unproven drugs. Doctors who have dispensed the drug are convinced that it works, but all the conventional controlled studies have not been done. Nonetheless, the FDA last week approved ganciclovir for full marketing and sales. The agency also gave the go-ahead for wider distribution of another unproven drug, erythropoietin, which is used in cases of AIDS-associated anemia...
Although FDA officials dispute the notion, some experts are concerned that the use of unproven medications may be getting out of control. So many AIDS patients are taking a pharmacological stew of approved and experimental drugs and potions that it is difficult to gauge the effectiveness of any single drug. Underground studies of experimental drugs, like the Compound-Q effort, confuse an already complex situation and frustrate scientists. "They're violating all the standards of safe testing of new compounds," says Dr. Paul Volberding, an AIDS specialist at the University of California at San Francisco. The haphazard use of experimental...