Word: used
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Dates: during 1980-1989
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...Compound-Q affair has heightened concern about the widespread use of unproven drugs. "There is always a tension between treatment of a patient and the need for solid drug testing," says Dr. Frank Young, the FDA commissioner. But AIDS has increased that tension. Those with the disease have protested for years that the FDA's traditional methods of testing an experimental drug's safety and effectiveness were too slow. "People have lost faith in the system," says Richard Dunne, executive director of Manhattan's Gay Men's Health Crisis...
Beginning in 1984, the FDA permitted the Syntex pharmaceutical firm to give doctors free ganciclovir, a drug used to treat eye infections that frequently blind AIDS patients, under a special program that allows "compassionate use" of unproven drugs. Doctors who have dispensed the drug are convinced that it works, but all the conventional controlled studies have not been done. Nonetheless, the FDA last week approved ganciclovir for full marketing and sales. The agency also gave the go-ahead for wider distribution of another unproven drug, erythropoietin, which is used in cases of AIDS-associated anemia...
Although FDA officials dispute the notion, some experts are concerned that the use of unproven medications may be getting out of control. So many AIDS patients are taking a pharmacological stew of approved and experimental drugs and potions that it is difficult to gauge the effectiveness of any single drug. Underground studies of experimental drugs, like the Compound-Q effort, confuse an already complex situation and frustrate scientists. "They're violating all the standards of safe testing of new compounds," says Dr. Paul Volberding, an AIDS specialist at the University of California at San Francisco. The haphazard use of experimental...
...citizens to start large-scale private businesses and hire up to 500 workers. A fledgling stock market has 147 listings. Within three years, half of Hungary's economy is expected to be in private hands. Consumer goods are expensive, but, unlike in Poland, they are plentiful. Hungarians proudly use the phrase "like < an American movie" to describe their store shelves and dinner tables...
During the spiritually enervating marathon that passed as the 1988 campaign, presidential candidates were forced to refute publicly rumors of homosexuality, mental illness, illegal-drug use and extramarital affairs. Yet the Donna Rice episode, following months of pious denials of womanizing by Gary Hart, can only have strengthened the public's cynical suspicion that smoke inevitably signals an inferno of secret scandal. Hart's dramatic downfall was an embarrassing spectacle, especially for all the journalists who missed the story. Pam Maples, a political reporter for The Rocky Mountain News in Denver, expressed a typical reaction: "This paper has tended...