Word: vaccinees
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Dates: during 2000-2009
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Researchers announced this week the early trial results of a new vaccine to fight cocaine addiction - a compound that, by vaccine standards, was only mildly effective but served as an important proof of concept that vaccination against addiction could work.
"Vaccines are one of our top priorities," says Dr. Nora Volkow, director of the National Institute on Drug Abuse (NIDA), which helped fund the study and will finance a larger study of the cocaine vaccine next year. In September, NIDA also granted $10 million for a clinical trial to the...
In the new study, published in the October issue of the Archives of General Psychiatry, researchers recruited 115 cocaine-dependent people who were also addicted to heroin and enrolled in a methadone-treatment program, which made it easier for investigators to keep people in the study for a full 12...
The vaccine produced a strong antibody response in 38% of the 55 people who received all five doses. When antibody levels were highest - during weeks 9 through 16 of the trial - these participants used significantly less cocaine (as measured by urine samples taken three times a week) than either the...
Another issue is that the vaccine would require booster shots to maintain a consistent level of antibodies, so Volkow suggests that a successful vaccine would in theory be most useful for relapse prevention, rather than to initiate abstinence. "If you give it to someone who has gone through rehab and...