Word: vaccinees
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Dates: during 2000-2009
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Today, 25 years and many failed attempts later, an AIDS vaccine seems as elusive as ever. New HIV infections still greatly outpace the number of people being brought onto antiretroviral treatment, with some 2.5 million new HIV cases worldwide in 2007, including nearly half a million children. That same year...
Back at square one, a group of researchers at Rockefeller University in New York City have some new ideas - and no shortage of optimism - about how to find the holy grail of AIDS research. Their approach to vaccine development, outlined online on March 15 in the journal Nature, is to...
To be sure, creating an effective vaccine from the Rockefeller scientists' research will not be easy, and it certainly will not be quick. Still, this work is "identifying possible targets in the virus, and that's really the exciting part of it," says Dr. Adel Mahmoud, a lecturer at Princeton...
In fact, the search for an AIDS vaccine has been thwarted over and over by the tricky, unexpected nature of HIV, whose behavior is only now coming to be understood. The human immune system does not appear to develop an effective response to HIV simply by being exposed to a...
This was the approach used by VaxGen's AIDSVax, the only AIDS vaccine candidate that has so far made it to Phase III testing, the final stage before clinical approval. That vaccine was designed to spark an immune response to a surface protein called gp120. But results of that trial...