Word: vaccinees
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But while initiatives to provide insecticide-treated bed nets and other control measures have cut malaria rates in half in some countries, the disease is adapting, and insecticide-resistant and treatment-resistant strains are increasingly problematic. And the worldwide recession is reducing the funding available to keep malaria-control initiatives...
The new vaccine is not the first TBV attempted. Previous versions used not AnAPN1 but parts of the malaria parasite to generate human immune responses. Unfortunately, two vaccine candidates using that approach unexpectedly caused some skin disorders when tested in humans in 2008, prompting a need for further research. And...
Malaria TBVs can be problematic, and not just because none has been perfected yet. People would have to step forward to receive a vaccine that would not make them immune to malaria; they would instead become part of a growing web of people who would eventually push the parasite out...
To make a TBV more more attractive, then, epidemiologists do not plan to administer it by itself. Rather, it would be given along with a traditional immunity-conferring vaccine. "Not a single person thinks that you should give a transmission-blocking vaccine alone," says Dinglasan. "You'd give it in...
This would also help the vaccine get past regulators at agencies like the FDA. Medications are approved based on an "indication," a medical problem or risk suffered by an individual. If a TBV were not part of a combination vaccine, this "indication" would be hard to define. Of course, the...