Word: vaccinees
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HMS Higgins Professor of Microbiology and Molecular Genetics David Knipe, who has been developing a vaccine for 15 years, said he discovered it unexpectedly after testing mice with mutant viruses.
“The vaccine is a genetically engineered virus missing essential replication genes,” Knipe said.
He explained that the vaccine prevents herpes because it causes the virus to only partially complete its replication process.
Currently, there is no cure for HSV-2, the sexually transmitted variant, which affects about one out of every five Americans over the age of 12. Knipe’s vaccine targets HSV-2, which is also responsible for oral herpes, or cold sores.
The search for a herpes vaccine closely parallels that for the cure for HIV, the virus that causes AIDS, since the prevention of both viruses involves the generation of antibodies and T-cells. While acknowledging that his research provides new hope for the possibility of an HIV vaccine, Knipe said...