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But what they got, once they joined McGee's clinical trial, many patients say, was a different story. According to Mathias, more than a third developed severe side effects, including uncontrollable nausea, fevers, rashes, swelling and terrible headaches. Some thought the doctor's behavior was odd. While on the vaccine...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

Still, Mathias says, most of McGee's patients believed that this vaccine was their best chance for recovery from what is usually a fatal disease. That's why they were so shocked when McGee sent them a letter that read, in part, "Patients have enrolled in this study more rapidly...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

The letter was devastating enough, but Mathias knew it was a lie. The truth was that the trial had been suspended out of a growing concern among McGee's supervisors that it may have been doing more harm than good. So after agonizing for days about what to do, she...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

The lesson would have been a lot less shocking if McGee's vaccine trial had been run out of a back-alley clinic or a storefront in Tijuana. In fact, the study was conducted at the St. John Medical Center in Tulsa, Okla., and co-sponsored by the respected University...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

It's hard to believe, but as recently as 1974 individual scientists and their financial backers could decide for themselves what constituted ethical research. Most of the time their judgment was sound, but there were plenty of appalling exceptions. In the 1950s Army doctors gave LSD to soldiers without telling...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

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