Word: vaccinees
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At present, the likelihood that this particular vaccine or this particular secretase inhibitor will end up in the therapeutic arsenal has to be considered slim. Of all the compounds his team brings forward, says Molinoff, only 10% to 15% manage to pass the rigorous series of tests that lead to...
R. Dani Bolognesi still remembers the afternoon in 1994 when one of his research colleagues, Tom Matthews, ran into his office at Duke University with some exciting news. While searching for something that might work as a vaccine against HIV, Matthews had stumbled upon a compound that blocked the AIDS...
It turns out that the compound Matthews identified doesn't work as an AIDS vaccine, but it may still make a very good AIDS drug. It belongs to a family of molecules known as entry inhibitors that, as the name suggests, prevent HIV's entry into healthy immune cells. While...
"I used to think plaques were like bits of concrete scattered throughout the brain," says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his...
Other companies are focused on boosting the immune system with vaccines that can direct it to target cancer cells. A new vaccine developed at Memorial Sloan-Kettering binds a protein from a mollusk called a limpet to seven different types of sugars and a protein fragment found only on cancer...