Word: vaccinees
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What might have been a methodical, scientific quest has turned into a wild crapshoot. In more than 60 laboratories around the world, researchers are working with at least 40 different concoctions in pursuit of one of medicine's most urgent goals: the development of an AIDS vaccine. Any team that...
But first it will be necessary to bring some order to the bewildering array of options. While there are still some doubts that an ideal vaccine can actually be created, some researchers believe that enough good candidates now exist to warrant drastically narrowing the search and selecting the best and...
But even early planning for such experiments has raised thorny economic, political and ethical questions that some researchers fear could interfere with the introduction of a lifesaving vaccine. "If one of these trials goes badly, we would lose not only time, but we could lose the opportunity to test an...
The basic principle behind such human tests has changed little since the 19th century. Several thousand people at high risk for the disease will be inoculated with the experimental agent, most likely an altered version of the AIDS virus (HIV) or some portion of it. The vaccine should not be...
Scientists, moreover, cannot guarantee that these trials will be risk free. If a vaccine is made from a whole AIDS virus, for example, there will be a slight danger that some of those vaccinated will get the disease. In 1955, during early testing of the polio vaccine, 80 children in...