Word: vaccinees
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Two serious men have attempted an answer. One is Jonas Salk. "When you inoculate children with a polio vaccine," he said of his early clinical tests, "you don't sleep well for two or three months." So Salk tested the vaccine on himself, his wife and his own children...
All vaccines work by teaching the immune system to recognize the face of the enemy. Once the body knows the chemical features, or antigens, of an infectious agent, it can produce specific weapons, or antibodies, against it. With malaria, however, there are three faces to recognize. Each stage is marked...
The advent of genetic engineering in the 1970s made such tedious work obsolete. Using methods for dissecting molecules, the two groups of researchers reporting in Science were able to identify the specific antigen, found on the surface of the sporozoite, that is responsible for producing immunity to this stage of...
Most malariologists agree that the ideal way to prevent the disease would be with a "cocktail" of vaccines for all three stages. Progress toward that end is now moving swiftly. Researchers in Geneva and Melbourne have been so successful in identifying antigens of the merozoite that they plan to begin...
New methods of mosquito control are also vital. The challenge is to produce insecticides that are environmentally safe and that can overcome the problem of resistance. Entomologist Brian Federici, a WHO consultant at the University of California, Riverside, may have found a way of solving these two problems by spraying...