Word: vaccinees
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Last week the magazine climaxed a yearlong celebration of its 50th birthday with a black-tie party for 2,000 people in New York City's Avery Fisher Hall. They gathered to honor a self-conscious "publishing event": a 616-page special issue of Esquire, hailing "50 Americans who...
The immediate targets are herpes, hepatitis and influenza, but the potential is much greater. Last week a group of scientists with the New York State department of health announced an exciting and imaginative application of the genetic-engineering techniques that are transforming modern medicine. Using the sophisticated new cut-and...
The starting point for the dramatic research is the oldest vaccine on earth: a smallpox prophylactic made from a live cowpox virus called vaccinia. It was developed two centuries ago by Edward Jenner, a British physician who had observed that milkmaids exposed to cowpox were immune to smallpox. Because vaccinia...
What Paoletti and his colleague, Virologist Dennis Panicali, set out to do was to alter the genetic material, or DNA, of cowpox virus by inserting a gene from another virus-herpes, hepatitis B or influenza (see diagram). The goal of these microscopic manipulations is to develop a vaccine that will...
When tested in rabbits, the genetically engineered formulas proved to be able deceivers, eliciting large quantities of antibodies to hepatitis B, herpes simplex or flu. More impressive still was a study performed by a team at the National Institute of Allergy and Infectious Diseases (NIAID) showing that chimpanzees immunized with...