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Last week the magazine climaxed a yearlong celebration of its 50th birthday with a black-tie party for 2,000 people in New York City's Avery Fisher Hall. They gathered to honor a self-conscious "publishing event": a 616-page special issue of Esquire, hailing "50 Americans who...

Author: /time Magazine | Title: Press: Esquire at Mid-Century | 11/21/1983 | See Source »

The immediate targets are herpes, hepatitis and influenza, but the potential is much greater. Last week a group of scientists with the New York State department of health announced an exciting and imaginative application of the genetic-engineering techniques that are transforming modern medicine. Using the sophisticated new cut-and...

Author: /time Magazine | Title: Medicine: Made-to-Order Vaccines | 10/31/1983 | See Source »

The starting point for the dramatic research is the oldest vaccine on earth: a smallpox prophylactic made from a live cowpox virus called vaccinia. It was developed two centuries ago by Edward Jenner, a British physician who had observed that milkmaids exposed to cowpox were immune to smallpox. Because vaccinia...

Author: /time Magazine | Title: Medicine: Made-to-Order Vaccines | 10/31/1983 | See Source »

What Paoletti and his colleague, Virologist Dennis Panicali, set out to do was to alter the genetic material, or DNA, of cowpox virus by inserting a gene from another virus-herpes, hepatitis B or influenza (see diagram). The goal of these microscopic manipulations is to develop a vaccine that will...

Author: /time Magazine | Title: Medicine: Made-to-Order Vaccines | 10/31/1983 | See Source »

When tested in rabbits, the genetically engineered formulas proved to be able deceivers, eliciting large quantities of antibodies to hepatitis B, herpes simplex or flu. More impressive still was a study performed by a team at the National Institute of Allergy and Infectious Diseases (NIAID) showing that chimpanzees immunized with...

Author: /time Magazine | Title: Medicine: Made-to-Order Vaccines | 10/31/1983 | See Source »

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