Word: vaccinees
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The vaccine, called RV144, combined two older vaccines that had each proved unsuccessful in previous tests: ALVAC, from Sanofi Pasteur, the vaccine division of French drugmaker Sanofi-Aventis; and AIDSVAX, originally developed by VaxGen Inc. and now held by the nonprofit Global Solutions for Infectious Diseases.
The vaccine was administered in two stages. First the ALVAC vaccine, which uses a Frankenstein virus of canarypox and HIV, was used as a primer dose, then AIDSVAX was administered as a "booster" to improve the body's immune response to the first shot. Half of the trial's participants...
An AIDS vaccine has been shown to reduce the risk of HIV infection in humans for the first time, a significant advance in a field of research that has long been stymied by failure.
The $105 million, six-year trial, which involved more than 16,000 people in Thailand - the largest AIDS-vaccine trial ever conducted - found that an experimental vaccine was 31% effective in preventing HIV infection. The volunteer group in the study was representative of the general Thai adult population, including low...
The vaccine will pose a special dilemma for everyone measuring the risks this fall. We already know there will not be enough vaccine for everyone right away. So the priority will be to vaccinate high-risk people, such as those with chronic conditions like diabetes. But high-risk people tend...