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In order to deliver the greatest benefit to at-risk populations in the developing world, OTD’s strategy focuses on two areas that act as force multipliers: infectious disease (the leading cause of preventable infant and child mortality in poor countries) and diagnostic technologies. A single dose of...

Author: By Isaac T. Kohlberg | Title: Advanced Global Access | 3/31/2009 | See Source »

The college-industrial complex periodically promotes some “highly promising” research, which will illicit massive funding. In the ‘70s , investigators said they were within “striking distance” of understanding cancer cells, in 1984 AIDS specialists predicted a vaccine within...

Author: By Stephen Helfer | Title: No Cause for "Cell-ebration" | 3/19/2009 | See Source »

This was the approach used by VaxGen's AIDSVax, the only AIDS vaccine candidate that has so far made it to Phase III testing, the final stage before clinical approval. That vaccine was designed to spark an immune response to a surface protein called gp120. But results of that trial...

Author: /time Magazine | Title: A New Approach to Designing the AIDS Vaccine | 3/16/2009 | See Source »

Today there are a few other candidates in early phase trials, including compounds of two previously tested candidates, just in case they turn out to be effective together where each failed individually. Since Merck's setback in 2007, however, some scientists have questioned current vaccine-development tactics. And some researchers...

Author: /time Magazine | Title: A New Approach to Designing the AIDS Vaccine | 3/16/2009 | See Source »

"But if the antibodies are there to begin with" - introduced via vaccine, for example - "they can prevent the infection," says Nussenzweig. "I think they could provide high-grade immunity if they were present in high-enough quantities before infection - but they'd have to be there beforehand."

Author: /time Magazine | Title: A New Approach to Designing the AIDS Vaccine | 3/16/2009 | See Source »

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